Clinical Studies – Targeting Acute and Chronic Thromboembolic Disorders

Major Studies

A Study of Flexible Dosage in Extended PE/DVT Treatment

Major Studies

Register to gain access to personalised information regarding Brand, the indications your are treating regularly, dosing guidelines and resources such as Major Studies, Patient Information and short videos curated to your special interest.

EINSTEIN CHOICE:
A Study of Xarelto^® with a Flexible Choice of Dosage for Extended Treatment of Recurrent VTE

Objective

To compare the efficacy and safety profile of 20 mg OD or 10 mg OD Xarelto doses with aspirin for extended treatment of recurrent VTE , in patients who had been treated for 6–12 months with an anticoagulant therapy1

Study Design

EINSTEIN CHOICE is a randomised, double-blind, active-controlled, event-driven, superiority, Phase 3 study1
The primary efficacy outcome was symptomatic, recurrent, fatal or non-fatal VTE , and the principal safety outcome was major bleeding1

* ≤7 days of treatment interruption prior to randomisation. ^†Patients randomised after the requisite number of primary efficacy outcomes was reached were treated for ≥6 months.

Patients’ Clinical Characteristics

Key Findings

Efficacy
- Both 10 mg OD and 20 mg OD Xarelto doses significantly reduced the risk of recurrent VTE vs aspirin^‡,1
Safety
- Both 10 mg OD and 20 mg OD Xarelto doses demonstrated a low risk of major bleeding, similar to aspirin^‡,1
- Overall rates of major and clinically relevant non-major bleeding were similar between both Xarelto doses and aspirin^‡,1

DVT , deep vein thrombosis ; OD, once daily; PE , pulmonary embolism; VTE , venous thromboembolism.
^‡For VTE extended treatment.

PP-XAR-ALL-1816-1

References

Weitz JI, et al. N Engl J Med. 2017;376:1211–1222. Weitz JI, et al. N Engl J Med. 2017;376:1211–1222. Return to content

Clinical Studies – Targeting Acute and Chronic Thromboembolic Disorders

A Study of Flexible Dosage in Extended PE/DVT Treatment

DOSING GUIDE

PRACTICAL MANAGEMENT

PRESCRIBING INFORMATION

EINSTEIN CHOICE:
A Study of Xarelto^® with a Flexible Choice of Dosage for Extended Treatment of Recurrent VTE

References

If you would prefer to visit your local website, please select your country:

Clinical Studies – Targeting Acute and Chronic Thromboembolic Disorders

A Study of Flexible Dosage in Extended PE/DVT Treatment

DOSING GUIDE

PRACTICAL MANAGEMENT

PRESCRIBING INFORMATION

EINSTEIN CHOICE: A Study of Xarelto® with a Flexible Choice of Dosage for Extended Treatment of Recurrent VTE

References

EINSTEIN CHOICE:
A Study of Xarelto^® with a Flexible Choice of Dosage for Extended Treatment of Recurrent VTE